Dr. Leung Kam Tong

Personal Information

Dr. Leung Kam Tong

BSc, MPhil, PhD (CUHK)

 

Email : ktleung@cuhk.edu.hk

Biography

Dr. KT Leung obtained his PhD degree and had his postdoctoral training in the Department of Paediatrics, The Chinese University of Hong Kong. He then took up an academic post with CUHK in 2014. Dr Leung has established research interest in various aspects of hematology, including hematopoietic stem cells and pediatric hematologic malignancies. He is also working on the pathophysiology and biomarkers of neonatal infections and necrotizing entercolitis. 

Research Opportunities
We are seeking postgraduate students who are interested in stem cell and leukemia research, or pathogenesis of neonatal infection and bowel diseases. Interested candidate please send a CV to Dr KT Leung.
 

Current appointments

  • Research Assistant Professor (since 2014)

 

Research Interest

  • Hematology/Oncology
    • Molecular mechanisms of hematopoietic stem cell homing, engraftment and mobilization
    • Development of targeted therapy for pediatric malignancies

  • Neonatology 
    • Role of hematopoietic stem cells in neonatal infections and necrotizing enterocolitis
    • Pathogenesis of necrotizing enterocolitis and spontaneous intestinal perforation
    • Biomarkers of neonatal infections and necrotizing enterocolitis

 

Recent Publications

  1. Leung KT, Chan KY, Ma TP, Yu JW, Tong HM, Tam YH, Cheung HM, To KF, Lam HS, Lee KH, Li K, Ng PC. Dysregulation of Arginine Metabolism in Human Intestinal Tissues of Necrotizing Enterocolitis. 2015 (submitted).

  2. Chan KY, Leung KT (co-first author), Tam YH, Lam HS, Cheung HM, Ma TP, Lee KH, To KF, Li K, Ng PC. Genome-wide Expression Profiles of NEC versus SIP in Human Intestinal Tissues: Dysregulation of Functional Pathways. Ann Surg 2014; 260(6):1128-1137.  

  3. Lee KY, Chan KY, Tsang KS, Chen YC, Kung HF, Ng PC, Li CK, Leung KT, Li K. Ubiquitous expression of MAKORIN-2 in normal and malignant hematopoietic cells and its growth promoting activity. PLoS One 2014; 9(3):e92706.  

  4. Fong ON, Chan KY, Leung KT, Lam HS, Cheung HM, Leung TY, Li K, Ng PC. Expression profile of cord blood neutrophils and dysregulation of HSPA1A and OLR1 upon challenge by bacterial peptidoglycan. J Leukoc Biol 2014; 95(1):169-178.  

  5. Lam HS, Cheung HM, Poon TC, Wong RP, Leung KT, Li K, Ng PC. Neutrophil CD64 for Daily Surveillance of Systemic Infection and Necrotizing Enterocolitis in Preterm Infants. Clin Chem 2013; 59(12):1753-1760.  

  6. Ng EW, Poon TC, Lam HS, Cheung HM, Ma TP, Chan KY, Wong RP, Leung KT, Lam MM, Li K, Ng PC. Gut-associated biomarkers L-FABP, I-FABP, and TFF3 and LIT score for diagnosis of surgical necrotizing enterocolitis in preterm infants. Ann Surg 2013; 258(6):1111-1118.  

  7. Chan KY, Leung FW, Lam HS, Tam YH, To KF, Cheung HM, Leung KT, Poon TC, Lee KH, Li K, Fok TF, Ng PC. Immunoregulatory protein profiles of necrotizing enterocolitis versus spontaneous intestinal perforation in preterm infants. PLoS One 2012; 7(5):e36977.  

  8. Leung KT, Chan KY, Ng PC, Lau TK, Chiu WM, Tsang KS, Li CK, Kong CK, Li K. The tetraspanin CD9 regulates migration, adhesion and homing of human cord blood CD34+ hematopoietic stem/progenitor cells. Blood 2011; 117(6): 1840-1850.  

  9. Leung KT, Li K, Sun SM., Chan PK, Ooi VEC, Chiu LC. Activation of the JNK pathway promotes phosphorylation and degradation of BimEL – a novel mechanism of chemoresistance in T-cell acute lymphoblastic leukemia. Carcinogenesis 2008;29(3): 544-551.  

  10. Leung KT, Chiu LC, Li Y, Sun SM, Ooi VE. In vitro antiviral activities of Chinese medicinal herbs against duck hepatitis B virus. Phytotherapy Research 2006; 20(10): 911-914.  

  11. Su M, Li Y, Leung KT, Cen Y, Li T, Chen R, Ooi VE. Antiviral activity and constituent of Ardisia chinensis Benth against coxsackie B3 virus. Phytotherapy Research 2006; 20(8): 634-639.  

  12. Li Y, Leung KT, Yao F, Ooi SM, Ooi VE. Li Y. Antiviral flavans from the leaves of Pithecellobium clypearia. Journal of Natural Products 2006; 69(5): 833-835.  

  13. Lam WY, Leung KT, Law PT, Lee SM, Chan HL, Fung KP, Ooi VE, Waye MM. Antiviral effect of Phyllanthus nanus ethanolic extract against hepatitis B virus (HBV) by expression microarray analysis. Journal of Cellular Biochemistry 2006; 97(4): 795-812.

DEPARTMENT OF PAEDIATRICS

Faculty of Medicine

The Chinese University of Hong Kong

6/F Lui Che Woo Clinical Sciences Building

Prince of Wales Hospital

Shatin

HONG KONG

Office Hours:

08:45 - 13:00 and 14:00 - 17:30 (Mon - Thur)

08:45 - 13:00 and 14:00 - 17:45 (Fri)

Email:  paediatrics@cuhk.edu.hk

Tel:       +852 3505-2851

Fax:      +852 2636-0020

Copyright © 2018.

All Rights Reserved.

The Chinese University of Hong Kong.

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