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Garlic

Telephone (office): (852) 3513-3176

E-mail:    ktleung@cuhk.edu.hk

Publons: I-8569-2017


Administrative support: Ms Stella Chan 

Telephone (office): (852) 3505-2849

Professor LEUNG Kam Tong
梁錦堂教授

  • Assistant Professor, Department of Paediatrics

BSc (Biology), MPhil (Biology), PhD (Medical Sciences)

Research Team: Paediatric Haematology & Oncology

Biography

Dr. KT Leung did his PhD and postdoctoral training in the Department of Paediatrics, CUHK from 2006 to 2014, and thereafter started his academic career in the same Department and currently leads a young but ambitious Paediatric Haematology/Oncology Research Team in the Hong Kong Children’s Hospital, comprising 4 postdoctoral fellows, 5 PhD/MPhil students and 4 research assistants.


He is a dedicated haematologist with ample experience in translational research of blood diseases. His laboratory primarily focuses on deciphering the molecular mechanisms of haematopoietic stem cell trafficking and deriving novel targeted therapies for childhood acute leukemia. He published in leading journals in the field of Hematology, including Blood, Blood Cancer Discovery, Blood Advances and Leukemia, and has obtained 25 research grants (14 as PI; HKD 17.3 million) including external competitive RGC, HMRF and ITF fundings.

Research Interests

  • Therapeutic antibodies and small-molecule inhibitors for childhood acute leukemia

  • Functional genomics of childhood acute leukemia and its application for precision medicine

  • Immunology of childhood acute leukemia and chimeric antigen receptor T cells

  • Molecular mechanisms of hematopoietic stem cell transplantation


Professional Service

  • Member, International Society of Paediatric Oncology

  • Member, Hong Kong Society of Haematology

  • President and Council Member, Hong Kong Society of Flow Cytometry

  • Member, European Hematology Association

  • Member, Hong Kong Paediatric Haematology & Oncology Study Group

  • Associate Editor, Journal of Cellular and Molecular Medicine


Awards

  • Young Investigator Award, International Society of Paediatric Oncology, 2019

  • Best Abstract Award, Hong Kong Society of Haematology, 2019

  • Travel Award, European Hematology Association, 2018

  • Abstract Achievement Award, American Society of Hematology, 2013

  • Abstract Achievement Award, American Society of Hematology, 2007

  • TY Wong Innovation and Entrepreneurial Fellowship, CUHK, 2003

  • Ho Tim Scholarship, CUHK, 2002

  • Dean’s Honours List, Faculty of Science, CUHK, 2001, 2002

  • United College Endowment Fund Prize, CUHK, 2001, 2002

  • Wu Chung Scholarship, CUHK, 2001


Patents

  • U.S. Patent 15/653,325: CD9 as a therapeutic target for hematologic malignancies


Publicity

Selected Publications

  1. Wang H, Chan KYY, Cheng CK, Ng MHL, Lee PY, Cheng FWT, Lam GKS, Chow TW, Ha SY, Chiang AKS, Leung WH, Leung AYH, Wang CC, Zhang T, Zhang XB, So CC, Yuen YP, Sun Q, Zhang C, Xu Y, Cheung JTK, Ng WH, Tang PM, Kang W, To KF, Lee WYW, Wong RSM, Poon ENY, Zhao Q, Huang J, Chen C, Yuen PMP, Li CK, Leung AWK, Leung KT. Pharmacogenomic profiling of pediatric acute myeloid leukemia to identify therapeutic vulnerabilities and inform functional precision medicine. Blood Cancer Discov. 2022; 3(6):516-535. [featured on journal cover]

  2. Chan KYY, Chung PY, Zhang C, Poon ENY, Leung AWK, Leung KT. R4 RGS proteins as fine tuners of immature and mature hematopoietic cell trafficking. J Leukoc Biol. 2022;112(4):785-797. [Review]

  3. Chan KYY, Zhang C, Wong YTS, Zhang XB, Wang CC, Ng WH, Fok SP, Tang PMK, Kang W, Feng B, Poon ENY, Lee KY, Lee CK, Chen C, Leung TY, Ng MHL, To KF, Wang H, Lam HS, Ng PC, Yuen PMP, Li K, Leung AWK, Li CK, Leung KT. R4 RGS proteins suppress engraftment of human hematopoietic stem/progenitor cells by modulating SDF-1/CXCR4 signaling. Blood Adv. 2021; 5(21):4380-4392.

  4. Leung KT, Zhang C, Chan KY, Li K, Cheung JT, Ng MH, Zhang XB, Sit T, Lee WY, Kang W, To KF, Yu JW, Man TK, Wang H, Tsang KS, Cheng FW, Lam GK, Chow TW, Leung AW, Leung TF, Yuen PM, Ng PC, Li CK*. CD9 blockade suppresses disease progression of high-risk pediatric B-cell precursor acute lymphoblastic leukemia and enhances chemosensitivity. Leukemia. 2020; 34(3):709-720.

  5. Leung KT, Lam HS, Chan KY, Sit T, Wong RP, Yu JW, Li K, Ng PC. Regulation of circulating hematopoietic stem/progenitor cells in preterm infants with septicemia. Stem Cells Dev. 2016; 25(23):1780-1787.

  6. Leung KT, Chan KY, Ng PC, Lau TK, Chiu WM, Tsang KS, Li CK, Kong CK, Li K. The tetraspanin CD9 regulates migration, adhesion and homing of human cord blood CD34+hematopoietic stem/progenitor cells. Blood. 2011; 117(6): 1840-1850.

  7. Leung KT, Li K, Sun SM, Chan PK, Ooi VE, Chiu LC. Activation of the JNK pathway promotes phosphorylation and degradation of BimEL – a novel mechanism of chemoresistance in T-cell acute lymphoblastic leukemia. Carcinogenesis.2008; 29(3): 544-551.

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