Dr. Leung Yat Hin Nicki
Dr. LEUNG Yat Hin Nicki
B.Sc (Hons), PhD (CUHK)
Dr. Nicki Leung obtained his PhD degree in the School of Life Sciences, The Chinese University of Hong Kong in 2015. During his PhD study, Dr. Leung has developed an interest in food (shellfish) allergy research, with focus on discovering novel strategy for allergen-specific immunotherapy and establishing food allergy animal models that resemble immunological and pathological features of allergic responses in human. His current research interest is in the diagnosis and treatment of fish allergy using molecular approaches.
Postdoctoral Fellow, Department of Paediatrics, The Chinese University of Hong Kong
Previous appointments and awards
Research Associate, Department of Paediatrics, The Chinese University of Hong Kong (2016-2018)
Research Associate, School of Life Sciences, The Chinese University of Hong Kong (2015-2016)
Outstanding Presentation Award, Hong Kong Inter-University Postgraduate Symposium in Life Sciences (2015)
Dr. Grace Chiu Po Yuen Memorial Prize, United College, The Chinese University of Hong Kong (2008-2009)
College Head’s List, United College, The Chinese University of Hong Kong (2008-2009)
Diagnosis of seafood allergy
1. Component-resolved diagnosis
2. Identification of novel allergens
3. Allergen quantification by mass spectrometry methods
Treatment of seafood allergy
1. Dose-dependent response of allergen-specific immunotherapy
2. Mimotope-based allergen-specific immunotherapy
3. Use of virus-like particles in allergen-specific immunotherapy
Animal model of seafood allergy
1. Routes of allergen sensitization and their immunopathology
2. In vivo characterization of allergen cross-reactivity
Wai, C.Y.Y., Leung, N.Y.H., Leung, P.S.C., Chu, K.H. 2017. Immunotherapy of food allergy: a comprehensive review. Clinical Reviews of Allergy & Immunology doi:10.1007/s12016-017-8647-y. [epub ahead of print]
Leung, N.Y.H., Wai, C.Y.Y., Shu, S.A., Chang, C.C., Chu, K.H. and Leung, P.S.C. 2017. Low-dose allergen-specific immunotherapy induces tolerance in a murine model of shrimp allergy. International Archives of Allergy & Immunology 174:86-96.
Leung, N.Y.H., Wai, C.Y.Y., Ho, M.H.K., Liu, R., Lam, K.S., Wang, J.J., Shu, S.A., Chu, K.H. and Leung, P.S.C. 2017. Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one-compound peptide libraries. Cellular & Molecular Immunology 14:308-318.
Leung, N.Y.H., Wai, C.Y.Y., Chu, K.H., Leung and P.S.C. 2017. Advances in seafood allergy research: Allergen detection and Allergen-specific immunotherapy. Food allergy – Methods of detection and clinical studies. New Hampshire, USA: Science Publishers.
Wai, C.Y.Y., Leung, N.Y.H., Leung, P.S.C., Chu, K.H. 2016. T cell epitope immunotherapy ameliorate allergic responses in a murine model of shrimp allergy. Clinical & Experimental Allergy 46(3):491-503.
Wai, C.Y.Y., Leung, N.Y.H., Ho, M.H.K., Gershwin, L.J., Shu, S.A., Leung, P.S.C., Chu, K.H. 2014. Immunization with hypoallergens of shrimp allergen tropomyosin inhibits shrimp tropomyosin specific IgE reactivity. PLoS One 9(11):e111649.
Leung, N.Y.H., Wai, C.Y.Y., Shu, S.A., Wang, J.J., Kenny, T.P., Chu, K.H. and Leung, P.S.C. 2014. Current immunological and molecular biological perspectives on seafood allergy: A comprehensive review. Clinical Reviews in Allergy & Immunology 46(3): 180-197.
Wai, C.Y.Y., Leung, N.Y.H., Chu K.H., Leung, P.S.C. 2012. From molecular studies of allergens to development of immunotherapies of allergies. Journal of Allergy & Therapy 3:3.
U.S. non-provisional patent (US9920100B2, Granted) Mimotopes of tropomyosin for use in immunotherapy for shellfish and/or arthropod allergy
U.S. non-provisional patent (US20170107265A1, Pending) Met e 1 tropomyosin variants for use in allergen-specific immunotherapy