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Garlic

E-mail:    tfleung@cuhk.edu.hk

Publons: E-7728-2013

ORCID:    0000-0002-6469-1926


Administrative support: Ms Angel Kwong

Telephone (office): (852) 3505-2981

Professor LEUNG Ting Fan
梁廷勳教授

  • Alice Ho Miu Ling Nethersole Charity Foundation Professor of Paediatrics, Department of Paediatrics

  • Co-Director, Chinese University of Hong Kong-Baylor College of Medicine Joint Center for Medical Genetics

  • Co-Director, Chinese University of Hong Kong-University Medical Center Utrecht Joint Research Laboratory of Respiratory Virus and Immunobiology

MBChB(CUHK), MD(CUHK), MRCP(UK), FRCPCH, FAAAAI, FHKCPaed, FHKAM(Paediatrics), Specialist in Paediatrics

Clinical Teams: Paediatric Immunology, Allergy and Infectious Diseases (Team Head), General Paediatrics

Research Team Website: Allergy CUHK

Biography

Professor Leung graduated from The Chinese University of Hong Kong in 1992, and he received subspecialty training on Immunology and Allergy in the Hospital for Sick Children in Toronto, Ontario, Canada in 1997-1998.  He was awarded Doctor of Medicine degree by The Chinese University of Hong Kong in 2004 for his research works on immunogenetics of childhood asthma.  Professor Leung was conferred as a First Fellow in Paediatric Immunology, Allergy and Infectious Diseases subspecialty by the Hong Kong College of Paediatricians in 2012.  Professor Leung is a professor in Department of Paediatrics of The Chinese University of Hong Kong since 2009, and he chaired this Department in 2014-2020.  He is also a visiting professor of the Central South University in Changsha, People’s Republic of China. Among many research achievements, Professor Leung was nominated to receive the Research Excellence in Allergic Diseases Award by the Hong Kong Institute of Allergy in September 2021. Professor Leung published more than 400 refereed journal articles and supervised sevenpost-doctoral fellows, 12 doctoral and 35 doctoral and master students as well as mentored 12 elite medical students under the Flagship programme Global Physician-Leadership Stream of the Faculty.

Research Interests

IMMUNOLOGY AND ALLERGY (免疫及過敏)

  • Natural history of childhood allergic diseases

  • Immunogenetics of asthma and eczema

  • Novel diagnosis and treatment for food allergy

  • Genetics and genomics of allergies

  • Host-microbe interactions as determinants for childhood allergies

INFECTIOUS DISEASES (兒童傳染病)

  • Emerging paediatric infectious diseases

  • Clinical trials on childhood vaccines


Honorary Appointments

  • Honorary Consultant Paediatrician, New Territories East Cluster, Kwong Wah Hospital and Hong Kong Children’s Hospital, Hospital Authority of Hong Kong

  • International Fellow, American Academy of Allergy Asthma and Immunology

  • Member, European Academy of Allergy and Clinical Immunology

  • Visiting Professor, Department of Pediatrics, Xiang Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China


Professional Service

  • Immediate Past President, Hong Kong Society for Paediatric Immunology Allergy and Infectious Diseases

  • Council Member, Hong Kong Paediatric and Adolescent Dermatology Society

  • Associate Editor, Frontiers in Pediatrics (Pulmonology)

  • Associate Editor, Asia Pacific Allergy

  • Associate Editor, Exploration of Asthma & Allergy

  • Editor, Journal of Formosans Medical Association

  • Review Editor, Frontiers in Allergy (Therapies, Therapeutic Targets & Mechanisms)


Academic Engagement in CUHK

  • Postgraduate supervision of seven post-doctoral fellows; 10 PhD, 11 MPhil and 19 MSc students graduated and two PhD, two MPhil and three MSc students under supervision

  • Academic mentor of two assistant professors and one clinical lecturer as well as supervisor of one Paediatric subspecialty trainee


Awards and Prizes

  • First runner-up for Young Investigator Award, International Paediatric Respiratory, Allergy and Immunology Congress. Hong Kong, July 2004

  • Young Researcher Award, 5th Asian Congress of Pediatric Infectious Diseases. Taipei, Taiwan, September 2010

  • Abstract Award, 31st Congress of European Academy of Allergy and Clinical Immunology.Geneva, Switzerland, June 2012

  • Best Poster Award, 17thCongress of Asian Pacific Society of Respirology. Hong Kong, December 2012

  • Abstract Prize, World Allergy and Asthma Congress. Milan, Italy, June 2013

  • Outstanding Abstract Award, 2013 Joint Congress of Asia Pacific Association of Pediatric Allergy, Respiratory and Immunology and Allergy, Asthma and Immunology Association of Thailand. Bangkok, Thailand, October 2013

  • Enhanced Travel Award, 34th Annual Meeting of European Society for Paediatric Infectious Diseases. Brighton, United Kingdom, May 2016

  • Best Poster Award (Clinical), Hong Kong Allergy Convention 2016. Hong Kong, October 2016

  • Best Poster Presentation Award, 13th Annual Congress of Asian Society for Pediatric Research. Hong Kong, October 2017

  • Best Free Paper Award, Joint Congress of Asia Pacific Association of Allergy, Asthma and Clinical Immunology and Asia Pacific Association of Pediatric Allergy, Respiratory and Immunology. Bangkok, Thailand, October 2018

  • Abstract Prize, 38th Congress of European Academy of Allergy and Clinical Immunology. Lisbon, Portugal, June 2019

  • Best Oral Presentation Award, Asia Pacific Association of Pediatric Allergy, Respirology and Immunology 2021 Congress. Seoul, Korea, May 2021

  • Best Poster Presentation Award, 50th Anniversary of Korean Academy of Allergy Asthma and Clinical Immunology International Congress. Seoul, Korea, May 2022

  • Best Poster Discussion Winner, Food Allergy and Anaphylaxis Meeting and European Consortium on Application of Flow Cytometry in Allergy Digital 2022 Meeting. Online, December 2022


Patents and Discoveries

  • “Improved accuracy of fish allergy diagnosis using grass carp allergens”, US Non-Provisional Patent Application; PCT International Application No. 16/588,517 filed on 30 Sep 2019 and published as Non-Provisional Patent under publication no. US2020/0191797 A1 on 18 Jun 2020

  • “Novel diagnostic allergen biomarkers for shrimp allergy”, US Non-Provisional Patent Application; PCT International Application No. 17/335,602 filed on 1 Jun 2021 and published as Non-Provisional Patent under publication no. US2021/0382070 A1 on 9 Dec 2021

  • “Forecasting developmental language and communication outcomes in healthy children”, for Chinese Patent Application no. 202010692253.5 filed on 17 Jul 2020 and approved on 5 Jan 2023 with publication no. 2022123002157840

  • “CD9 as a therapeutic target for hematologic malignancies”, US Provisional Patent PCT international application no. 15/653,325 filed on 18 Jul 2017

  • Discovery and registration of “Allergen structure of Ctenopharyngodon idella” in the WHO/IUIS Allergen Nomenclature Database and accepted as a new fish allergen with the name Cten i 1.0101; PubMed accession number GEUQ01011817.1 on 9 Jan 2019

  • Discovery and registration of “Allergen structure of Pen m 13 (fatty acid-binding protein [FABP]) of Penaeus monodon” in the WHO/IUIS Allergen Nomenclature Database and accepted as a new shrimp allergen with the name Pen m 13.0101; PubMed accession number GEUQ01011817.1 on 28 Oct 2019

  • Discovery and registration of “Allergen structure of Pen m 8 (triosephosphate isomerase [TIM]) of Penaeus monodon” in the WHO/IUIS Allergen Nomenclature Database and accepted as a new shrimp allergen with the name Pen m 8.0101; PubMed accession number GEUQ01011817.1 on 28 Oct 2019

  • Discovery and registration of “Allergen structure of Pen m 14 (glycogen phosphorylase [GP]-like protein) of Penaeus monodon” in the WHO/IUIS Allergen Nomenclature Database and accepted as a new shrimp allergen with the name Pen m 14.0101; GenBank Nucleotide number OM156460 on 4 Feb 2022

  • Discovery and registration of “Allergen structure of Pen m 7 (hemocyanin [GP]) of Penaeus monodon” in the WHO/IUIS Allergen Nomenclature Database and accepted as a new shrimp allergen with the name Pen m 7.0101; GenBank Nucleotide number JF357966.1 on 27 Aug 2021

  • Co-owner of copyright for “A validated short food frequency questionnaire for Chinese pregnant women”, led by Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong on and submitted for copyright assignment on 16 Aug 2021

  • Co-owner of copyright “The Way out of Eczema”, an eczema education booklet published by Nethersole School of Nursing, The Chinese University of Hong Kong on 10 Aug 2020

Selected Publications

  1. Wai CY*, Leung NY*, Leung AS, Ngai SM, Pacharn P, Yau YS, Rosa Duque JS, Kwan YW, Jirapongsananuruk O, Chan WH, Chua GT, Lee QU, Piboonpocanun S, Ho PK, Wong JS, Li S, Xu KJ, Wong GW, Chu KH, Leung PS, Vichyanond P, Leung TF (corresponding author). Comprehending the allergen repertoire of shrimp for precision molecular diagnosis of shrimp allergy. Allergy 2022; 77: 3041-3051. (* co-first authors)

  2. Hou J-P*, Song YP*, Leung AS, Tang MF, Shi M, Wang EY, Tsun JG, Chan RW, Wong GW, Tsui SK, Leung TF (corresponding author). Temporal dynamics of the nasopharyngeal microbiome and its relationship with childhood asthma exacerbation. Microbiology Spectrum 2022; 10: e0012922. (* co-first authors)

  3. Wai CY, Leung NY, Leung AS, Shum Y, Leung PS, Chu KH, Kwan YW, Lee QU, Wong JS, Lam IC, Li PF, Xu KJ, Lam CY, Sun JL, Wong GW, Leung TF (corresponding author). Cell-based functional IgE assays are superior to conventional allergy tests for shrimp allergy diagnosis. Journal of Allergy and Clinical Immunology: In Practice 2021; 9: 236-244.

  4. Leung AS*,Leung NY*, Wai CY, Xu KJ, Lam MC, Shum Y, Lee TH, Ho MH, Rosa Duque JS, Chua GT, Yau YS, Chan WH, Ho PK, Wong GW, Leung TF (corresponding author). Characteristics of Chinese fish-allergic patients: findings from double-blind placebo-controlled food challenges. Journal of Allergy and Clinical Immunology: In Practice 2020; 8: 2098-2100. (* co-first authors)

  5. Wang SS, Hon KL, Kong AP, Tang MF, Sy HY, Chan JC, Leung TF (corresponding author). Eczema phenotypes are associated with multiple vitamin D pathway genes in Chinese children. Allergy 2014; 69: 118-124.

  6. Leung TF, Ko FW, Sy HY, Tsui SK, Wong GW. Differences in asthma genetics between Chinese and other populations. Journal of Allergy and Clinical Immunology 2014; 133: 42-48.

  7. Leung TF, Ko FW, Wong GW. Roles of pollution in the prevalence and exacerbations of allergic diseases in Asia. Journal of Allergy and Clinical Immunology 2012; 129: 42-47.

  8. Leung TF (corresponding author), Sy HY, Wong GW, Ng MC, Chan IH, Li CY, Tang NL, Waye MM, Lam CW. Asthma and atopy are associated with chromosome 17q21 markers in Chinese children. Allergy 2009; 64: 621-628.

  9. Leung TF (corresponding author), Tang NL, Li CY, Lam CW, Wong GW, Fok TF. Association between TARC C-431T and atopy and asthma in children. Journal of Allergy and Clinical Immunology 2004; 114: 199-202.

  10. Leung TF (corresponding author), Wong CK, Chan IH, Ip WK, Lam CW, Wong GW. Plasma concentration of thymus and activation-regulated chemokine is elevated in childhood asthma. Journal of Allergy and Clinical Immunology 2002; 110: 404-409.

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