Neonatology

The Team

Clinical Services

The Neonatal Unit at the Prince of Wales Hospital is the only tertiary neonatal unit serving the New Territories East Region with a population of > 1 million and an annual delivery rate of 7,000

 

The Neonatal Intensive Care Unit (NICU)

The NICU consists of 21 beds and provides Level III Neonatal Intensive Care for critically ill newborns.  It is a modern unit equipped with state of the art technologies:

  • Advanced ventilatory supports – high frequency oscillatory ventilation (HFOV), patient-triggered ventilation and non-invasive ventilation

  • Inhaled nitric oxide (iNO) therapy – treatment of patients with pulmonary hypertension and cor pulmonale

  • Therapeutic hypothermia – treatment of newborns with moderate to severe hypoxic ischaemic encephalopathy (HIE)

  • Nutritional care of premature infants, as well as critically ill and surgical newborns

  • Post-operative care for neonatal surgical patients

  • Perinatal care together with obstetricians for high risk pregnancies

  • Other innovative treatments through our research protocols e.g., oral erythromycin prokinetic therapy for moderate to severe gastrointestinal dysmotility

 

The Special Care Baby Unit (SCBU)

The SCBU consists of 60 Level II special baby care beds providing care for:

  • Premature babies born greater than 32 weeks gestation

  • Newborns with medical or surgical problems but not requiring ventilatory support

  • Newborns recovering from serious conditions (step-down or intermediate care)

 

Neonatal Emergency Transport Service (NETS)

A dedicated transport team providing transport for critically ill neonates between the NNU at Prince of Wales Hospital and those of other regional hospitals in Hong Kong

 

Follow-up clinics

  • Following up NICU ‘graduates’ after discharge

  • Management of medical problems e.g., bronchopulmonary dysplasia, congenital disabilities

  • Assessing neurodevelopment

 

Research

The NNU team is very active in neonatal research.  Main themes included:

  • Biomarkers of neonatal infection

  • Steroid physiology in preterm infants

  • Treatment of gastrointestinal dysmotility in preterm infants

  • Prevention of parenteral nutrition related cholestasis (PNAC)

  • Intra-ocular pressure in preterm infants

  • NEC

 

Selected Research Grants

  1. Comparative investigation on NEC and SIP in preterm infants: differential cellular RNA expression in bowel tissue, and regulation of the FOXA1 and ARG1 signals
    RGC Earmarked Grant (2009-2010); PI: Prof Pak C. Ng; Amount awarded: $1,725,000

  2. A prospective clinical study to validate a diagnostic model on serum biomarkers, prior identified by quantitative proteomic profiling for early diagnosis of late-onset systemic infection in preterm infants
    RGC Earmarked Grant (2008-2009); PI: Prof Pak C. Ng; Amount awarded: $683,724

  3. Thrombopoietin protects against hypoxia-ischemia encepholopathy in murine model, and signals proliferation, anti-apoptosis and pro-survival in neural progenitorcells
    RGC Earmarked Grant (2006-2007); PI: Prof. T.F. Tok; Amount awarded: $654,500

  4. A quantitative evaluation of the neutrophil marker – CD64 for early diagnosis of necrotising enterocolitis in preterm infants
    RGC Earmarked Grant (2005-2006); PI: Prof Pak C. Ng; Amount award: $338,257

  5. A randomized, double-blind, controlled study of oral erythromycin for treatment of gastrointestinal dysmotility in preterm infants
    RGC Earmarked Grant (2002-2003); PI: Prof. Pak C. Ng; Amount award: $747,800

  6. A randomized, double-blinded, controlled study of two corticosteroid regimens for treatment of systemic hypotension in preterm infants
    RGC Earmarked Grants (2001-2002); PI: Prof. Pak C. Ng: Amount award: $765,000

 

Selected Publications

<A> Biomarkers of Neonatal Infection

  1. Ng PC, Ang IL, Chiu RW, Li K, Wong RPO, Chui KM, Sung JY, Lo YMD, Poon TCW.  Novel host response markers for accurate, early diagnosis of septicemia and necrotizing enterocolitis in preterm infants.  Journal of Clinical Investigations 2010; (in press).

  2. Chan KYY, Lam HS, Cheung HM, Chan KC, Li K, Fok TF, Ng PC.  Rapid identification and differentiation of Gram-negative and Gram-positive bacterial bloodstream infections by quantitative PCR in preterm infants.  Critical Care Medicine 2009;37:2441-7.

  3. Ng PC, Li K, Leung TF, Wong RPO, Li G, Chui KM, Wong E, Cheng FWT, Fok TF.  Early predication of sepsis-induced disseminated intravascular coagulation with interleukin-10, interleukin-6 and RANTES in preterm infants.  Clinical Chemistry 2006;52:1181-9.

  4. Ng PC, Li K, Chui KM, Leung TF, Wong RPO, Chu WCW, Wong E, Fok TF.  IP-10 is an early diagnostic marker for identification of late-onset bacterial infection in preterm infants.  Pediatric Research 2007;61:93-8.

  5. Ng PC, Li G, Chui KM, Chu WCW, Li K, Wong RPO, Chik KW, Wong E, Fok TF.  Neutrophil CD64 is a sensitive diagnostic marker for early-onset neonatal infection.  Pediatric Research 2004;56:796-803.

 

<B> Neonatal Gastroenterology

  1. Ng PC, Lee CH, Wong SPS, Lam HS, Liu FYB, So KW, Lee CY, Fok TF.  High-dose oral erythromycin decreased the incidence of parenteral nutrition-associated cholestasis (PNAC) in preterm infants with gastrointestinal dysmotility: A randomized double-blind controlled study.  Gastroenterology 2007;132:1726-39.

  2. Siu YK, Ng PC, Fung SCK, Lee CH, Wong MY, Fok TF, So KW, Cheung KL, Wong W, Cheng AFB.  Double-blind randomised placebo-controlled study of oral vancomycin in prevention of necrotising enterocolitis in preterm, very low birth weight infants.  Archives of Disease in Childhood Fetal and Neonatal Edition1998;79:F105-9.

  3. Cheung HM, Lam HS, Tam PYH, Lee KH, Ng PC.  Rescue treatment of infants with intestinal failure and parenteral nutrition-associated cholestasis (PNAC) using a parenteral fish-oil-based lipid.  Clinical Nutrition 2009;28:209-12.

 

<C> Neonatal Endocrinology

  1. Ng PC.  The effect of stress on the hypothalamic-pituitary-adrenal (HPA) axis in the fetus and newborn.  Journal of Pediatrics 2010; (in press).

  2. Ng PC.  Is there a ‘normal’ range of serum cortisol concentration for preterm infants?  Pediatrics 2008;122:873-5.

  3. Ng PC, Lee CH, Liu F, Chan IHS, Lee AWY, Wong E, Chan HB, Lam CWK, Lee BSC, Fok TF.  A double-blind, randomized, controlled study of a ‘stress dose’ of hydrocortisone for rescue treatment of refractory hypotension in preterm infants.  Pediatrics 2006;117:367-75.

  4. Ng PC, Lee CH, Lam CWK, Wong E, Chan IHS, Fok TF.  Plasma ghrelin and resistin concentrations are suppressed in infants of insulin-dependent diabetic mothers.  Journal of Clinical Endocrinology and Metabolism 2004;89:5563-8.

  5. Ng PC, Lam CWK, Lee CH, Ma KC, Fok TF, Chan IHS, Wong E.  Reference ranges and factors affecting the hCRH test in preterm, very low birth weight infants.  Journal of Clinical Endocrinology and Metabolism 2002;87:4621-8.

  6. Ng PC, Fok TF, Wong GWK, Lam CWK, Lee CH, Wong MY, Lam K, Ma KC.  Pituitary-adrenal suppression in preterm, very low birth weight infants after inhaled fluticasone propionate treatment.  Journal of Clinical Endocrinology and Metabolism 1998;83:2390-3.

  7. Ng PC, Wong GWK, Lam CWK, Lee CH, Fok TF, Wong MY, Wong W, Chan DCF.  Pituitary-adrenal suppression and recovery in preterm very low birthweight infants after dexamethasone treatment for bronchopulmonary dysplasia.  Journal of Clinical Endocrinology and Metabolism 1997;82:2429-32.

  8. Ng PC, Lee CH, Lam CWK, Ma KC, Fok TF, Chan IHS, Wong E.  Transient Adrenal insufficiency of Prematurity (TAP) and systemic hypotension in very low birth weight infant.  Archives of Disease in Childhood Fetal and Neonatal Edition  2004;89:F119-26.

  9. Ng PC, Lee CH, Lam CWK, Fok TF, Chan IHS, Ma KC, Wong E.  Early pituitary-adrenal response and respiratory outcomes in preterm infants.  Archives of Disease in Childhood Fetal and Neonatal Edition 2004;89:F127-30.

 

<D> General Neonatology

  1. Lam HS, Wong SPS, Wong HL, Liu FYB, Fok TF, Ng PC.  Attitudes to neonatal intensive care treatment of preterm infants with high risk of developing long-term disabilities.  Pediatrics2009;123:1501-8.

  2. Yang M, Li K, Ng PC, Chuen CKY, Lau TK, Cheng YS, Liu YS, Li CK, Yuen PMP, James AE, Lee SM, Fok TF.  Promoting effects of serotonin on hematopoiesis: Ex vivo expansion of cord blood CD34+ stem/progenitor cells, proliferation of bone marrow stromal cells and anti-apoptosis.  Stem Cell 2007;25:1800-6.

 

<E> International Collaborative Research

  1. HAPO Study Cooperative Research Group (Ng PC was the Chief Coordinator for Pediatricinvestigatorsin the Hong Kong region).  Hyperglycemia and adverse pregrancy outcome.  New EnglandJournal of Medicine 2008;358:1991-2002.

  2. Hyperglycemia and adverse pregnancy outcome (HAPO) study: Association with neonatal anthropometrics.  The HAPO Study Cooperative Research Group (Ng PC was the Chief Coordinator for Pediatric investigators in the Hong Kong region).  Diabetes 2009;58:453-9.

 

Educational activities

  • Advances in neonatal respiratory intensive care (co-organized with IPOKRaTES)

  • Diploma course in paediatric and neonatal critical care nursing

  • Weekly neonatal case presentation/standard operating procedure meeting

DEPARTMENT OF PAEDIATRICS

Faculty of Medicine

The Chinese University of Hong Kong

6/F Lui Che Woo Clinical Sciences Building

Prince of Wales Hospital

Shatin

HONG KONG

Office Hours:

08:45 - 13:00 and 14:00 - 17:30 (Mon - Thur)

08:45 - 13:00 and 14:00 - 17:45 (Fri)

Email:  paediatrics@cuhk.edu.hk

Tel:       +852 3505-2851

Fax:      +852 2636-0020

Copyright © 2018.

All Rights Reserved.

The Chinese University of Hong Kong.

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