Professor Lam Hugh Simon Hung San

Personal Information

Professor Lam Hugh Simon Hung San

MBBChir, DCH(HK), DCH(International), MRCPCH, FHKCPaed, FHKAM(Paed)

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Prof. Simon Lam is currently working as Professor at the Department of Paediatrics of The Chinese University of Hong Kong. He graduated from the University of Cambridge in 1998 and moved back to Hong Kong in 2000. His research interests are in neonatology, paediatric respiratory medicine and the environmental impact on child health. He is an American Academy of Pediatrics certified Neonatal Resuscitation Program Regional Trainer and teaches neonatal resuscitation at undergraduate as well as professional levels.


Current appointments

  • Professor, Department of Paediatrics, The Chinese University of Hong Kong, HK (2020-present)

  • Honorary Associate Consultant, Department of Paediatrics, Prince of Wales Hospital, HK (2008-present)

Previous appointments and awards

  • Associate Professor, Department of Paediatrics, The Chinese University of Hong Kong, HK (2011-2020)

  • Assistant Professor, Department of Paediatrics, The Chinese University of Hong Kong, HK (2008-2011)

  • Resident Specialist, Department of Paediatrics, Prince of Wales Hospital, HK (2007-2008)

  • Resident, Department of Paediatrics, Prince of Wales Hospital, HK (2001-2007)

  • Clinical Tutor, Department of Paediatrics, The Chinese University of Hong Kong, HK (2000-2001)


Research Interests

  • Neonatology
    o Neonatal infection markers
    o Neonatal parenteral nutrition
    o Parental attitudes to neonatal intensive care
    o Neonatal sleep patterns

  • Paediatric respiratory and sleep medicine
    o Inflammatory response to childhood obstructive sleep apnoea
    o Childhood sleep/wake patterns and health outcomes

  • Child health and environmental toxins
    o Prenatal mercury exposure and long-term childhood health outcomes
    o Childhood melamine exposure and long-term adverse health effects


Recent Publications

  1. Li AM, Au CT, Ng C, Lam HS, Ho CK, Wing YK. A four-year prospective follow-up study of childhood obstructive sleep apnea and its association with blood pressure. Chest. 2014 Jan 2. doi: 10.1378/chest.13-1333. [Epub ahead of print]

  2. Chan KY, Leung KT, Tam YH, Lam HS, Cheung HM, Ma TP, Lee KH, To KF, Li K, Ng PC. Genome-wide Expression Profiles of Necrotizing Enterocolitis Versus Spontaneous Intestinal Perforation in Human Intestinal Tissues: Dysregulation of Functional Pathways. Ann Surg. 2013 Dec 23. [Epub ahead of print]

  3. Au CT, Ho CK, Wing YK, Lam HS, Li AM. Acute and chronic effects of sleep duration on blood pressure. Pediatrics. 2014 Jan;133(1):e64-72. doi: 10.1542/peds.2013-1379. Epub 2013 Dec 16.

  4. Lam HS, Cheung HM, Poon TC, Wong RP, Leung KT, Li K, Ng PC. Neutrophil CD64 for daily surveillance of systemic infection and necrotizing enterocolitis in preterm infants. Clin Chem. 2013 Dec;59(12):1753-60. doi: 10.1373/clinchem.2013.209536. Epub 2013 Sep 17.

  5. Fong ON, Chan KY, Leung KT, Lam HS, Cheung HM, Leung TY, Li K, Ng PC. Expression profile of cord blood neutrophils and dysregulation of HSPA1A and OLR1 upon challenge by bacterial peptidoglycan. J Leukoc Biol. 2014 Jan;95(1):169-78. doi: 10.1189/jlb.0413219. Epub 2013 Aug 28.

  6. Nelson EA, Lam HS, Choi KC, Ho WC, Fung LW, Cheng FW, Sung RY, Royals M, Chan PK. A pilot randomized study to assess immunogenicity, reactogenicity, safety and tolerability of two human papillomavirus vaccines administered intramuscularly and intradermally to females aged 18-26 years. Vaccine. 2013 Jul 25;31(34):3452-60. doi: 10.1016/j.vaccine.2013.06.034. Epub 2013 Jun 12.

  7. Chan LC, Tam YH, Lam HS, Lee KH, Ng PC. Gastroschisis, omphalocele or something else? Arch Dis Child Fetal Neonatal Ed. 2014 Jan;99(1):F86. doi: 10.1136/archdischild-2013-303717. Epub 2013 Mar 26.

  8. Wang Q, Yin J, Xu L, Cheng H, Zhao X, Xiang H, Lam HS, Mi J, Li M. Prevalence of metabolic syndrome in a cohort of Chinese schoolchildren: comparison of two definitions and assessment of adipokines as components by factor analysis. BMC Public Health. 2013 Mar 21;13:249. doi: 10.1186/1471-2458-13-249.

  9. Ng EW, Poon TC, Lam HS, Cheung HM, Ma TP, Chan KY, Wong RP, Leung KT, Lam MM, Li K, Ng PC. Gut-associated biomarkers L-FABP, I-FABP, and TFF3 and LIT score for diagnosis of surgical necrotizing enterocolitis in preterm infants. Ann Surg. 2013 Dec;258(6):1111-8. doi: 10.1097/SLA.0b013e318288ea96.

  10. Lam HS, Kwok KM, Chan PH, So HK, Li AM, Ng PC, Fok TF. Long term neurocognitive impact of low dose prenatal methylmercury exposure in Hong Kong. Environ Int. 2013 Apr;54:59-64. doi: 10.1016/j.envint.2013.01.005. Epub 2013 Feb 13.

  11. Cheng SF, Ho JW, Chan KY, Leung TY, Lam HS, Fong ON, Li K, Ng PC. IL-15 and macrophage secretory factors facilitate immune activation of neonatal natural killer cells by lipoteichoic acid. Cytokine. 2013 Feb;61(2):499-505. doi: 10.1016/j.cyto.2012.10.034. Epub 2012 Nov 30.

  12. Ng EW, Lam HS, Ng PC, Poon TC. Quantification of citrulline by parallel fragmentation monitoring--a novel method using graphitized carbon nanoparticles and MALDI-TOF/TOF mass spectrometry. Clin Chim Acta. 2013 May;420:121-7. doi: 10.1016/j.cca.2012.10.039. Epub 2012 Nov 1.

  13. Hon KL, Lui H, Wang SS, Lam HS, Leung TF. Fish consumption, fish atopy and related heavy metals in childhood eczema. Iran J Allergy Asthma Immunol. 2012 Sep;11(3):230-5. doi: 011.03/ijaai.230235.

  14. Ng PC, Lam HS. Biomarkers in neonatology: the next generation of tests. Neonatology. 2012;102(2):145-51. doi: 10.1159/000338587. Epub 2012 Jun 29.

  15. Li AM, Au CT, Chook P, Lam HS, Wing YK. Reduced flow-mediated vasodilation of brachial artery in children with primary snoring. Int J Cardiol. 2013 Sep 1;167(5):2092-6. doi: 10.1016/j.ijcard.2012.05.108. Epub 2012 Jun 15.

  16. Chan KY, Leung FW, Lam HS, Tam YH, To KF, Cheung HM, Leung KT, Poon TC, Lee KH, Li K, Fok TF, Ng PC. Immunoregulatory protein profiles of necrotizing enterocolitis versus spontaneous intestinal perforation in preterm infants. PLoS One. 2012;7(5):e36977. doi: 10.1371/journal.pone.0036977. Epub 2012 May 14.

  17. Tam YS, Cheung HM, Tam YH, Lee KH, Lam HS, Poon TC, Ng PC. Clinical outcomes of congenital diaphragmatic hernia without extracorporeal membrane oxygenation. Early Hum Dev. 2012 Sep;88(9):739-41. doi: 10.1016/j.earlhumdev.2012.03.002. Epub 2012 Apr 11.

  18. Yu CC, Li AM, Au CT, McManus AM, So RC, Lam HS, Chu WC, So HK, Chiu WK, Leung CW, Yau YS, Fok TF, Sung RY. Follow up of aerobic capacity in children affected by severe acute respiratory syndrome. Respirology. 2012 Apr;17(3):513-8. doi:10.1111/j.1440-1843.2011.02125.x.

  19. Ng PC, Wong SP, Chan IH, Lam HS, Lee CH, Lam CW. A prospective longitudinal study to estimate the "adjusted cortisol percentile" in preterm infants. Pediatr Res. 2011 Jun;69(6):511-6. doi: 10.1203/PDR.0b013e31821764b1.

  20. Lam HS, Ng PC. Use of prokinetics in the preterm infant. Curr Opin Pediatr. 2011 Apr;23(2):156-60. doi: 10.1097/MOP.0b013e3283431f2a.

  21. Ng PC, Lam HS. Biomarkers for late-onset neonatal sepsis: cytokines and beyond. Clin Perinatol. 2010 Sep;37(3):599-610. doi: 10.1016/j.clp.2010.05.005.

  22. Lam HS, Wong SP, Cheung HM, Chu WC, Wong RP, Chui KM, Liu FY, Li K, Fok TF, Ng PC. Early diagnosis of intra-abdominal inflammation and sepsis by neutrophil CD64 expression in newborns. Neonatology. 2011;99(2):118-24. doi: 10.1159/000311289. Epub 2010 Aug 24.

  23. Ng PC, Ang IL, Chiu RW, Li K, Lam HS, Wong RP, Chui KM, Cheung HM, Ng EW, Fok TF, Sung JJ, Lo YM, Poon TC. Host-response biomarkers for diagnosis of late-onset septicemia and necrotizing enterocolitis in preterm infants. J Clin Invest. 2010 Aug;120(8):2989-3000. doi: 10.1172/JCI40196. Epub 2010 Jul 1.

  24. Hon KL, Wang SS, Hung EC, Lam HS, Lui HH, Chow CM, Ching GK, Fok TF, Ng PC, Leung TF. Serum levels of heavy metals in childhood eczema and skin diseases: friends or foes. Pediatr Allergy Immunol. 2010 Aug;21(5):831-6. doi: 10.1111/j.1399-3038.2010.01022.x. Epub 2010 Mar 19.

  25. Li AM, Abdullah VJ, Tsen CS, Au CT, Lam HS, So HK, Chan MH, Leung AW, Chan IH, Lam CW, Ng PC. Leukotriene receptor antagonist in the treatment of childhood allergic rhinitis--a randomized placebo-controlled study. Pediatr Pulmonol. 2009 Nov;44(11):1085-92. doi: 10.1002/ppul.21102.

  26. Chan KY, Lam HS, Cheung HM, Chan AK, Li K, Fok TF, Ng PC. Rapid identification and differentiation of Gram-negative and Gram-positive bacterial bloodstream infections by quantitative polymerase chain reaction in preterm infants. Crit Care Med. 2009 Aug;37(8):2441-7. doi: 10.1097/CCM.0b013e3181a554de.

  27. Lam HS, Wong SP, Liu FY, Wong HL, Fok TF, Ng PC. Attitudes toward neonatal intensive care treatment of preterm infants with a high risk of developing long-term disabilities. Pediatrics. 2009 Jun;123(6):1501-8. doi: 10.1542/peds.2008-2061.

  28. Li AM, Lam HS, So HK, Leung M, Tsen T, Au CT, Chang AB. Interrupter respiratory resistance in healthy Chinese preschool children. Chest. 2009 Aug;136(2):554-60. doi: 10.1378/chest.08-2798. Epub 2009 Apr 13.

  29. Cheung HM, Lam HS, Tam YH, Lee KH, Ng PC. Rescue treatment of infants with intestinal failure and parenteral nutrition-associated cholestasis (PNAC) using a parenteral fish-oil-based lipid. Clin Nutr. 2009 Apr;28(2):209-12. doi: 10.1016/j.clnu.2009.02.004. Epub 2009 Mar 4.

  30. Lam HS, Ng PC, Chu WC, Wong W, Chan DF, Ho SS, Wong KT, Ahuja AT, Li CK. Renal screening in children after exposure to low dose melamine in Hong Kong: cross sectional study. BMJ. 2008 Dec 18;337:a2991. doi: 10.1136/bmj.a2991.

  31. Li AM, Lam HS, Chan MH, So HK, Ng SK, Chan IH, Lam CW, Wing YK. Inflammatory cytokines and childhood obstructive sleep apnoea. Ann Acad Med Singapore. 2008 Aug;37(8):649-54.

  32. Chong JS, Tseung SY, Lam HS, Chu WC, Ip M, Wong HT, Zhu CX, Ng PC. Successful treatment of multiple subdural empyemata caused by Mycoplasma hominis in a newborn. Neonatology. 2009;95(2):179-82. doi: 10.1159/000153103. Epub 2008 Sep 6.

  33. Li AM, Tsang TW, Lam HS, Sung RY, Chang AB. Predictors for failed dose reduction of inhaled corticosteroids in childhood asthma. Respirology. 2008 May;13(3):400-7. doi: 10.1111/j.1440-1843.2007.01222.x. PubMed PMID: 18399863.

  34. Ng PC, Lee CH, Tam BS, Wong SP, Lam HS, Kwok AK, Fok TF. Transient increase in intraocular pressure during a dose-tapering regime of systemic dexamethasone in preterm infants. Ophthalmology. 2008 May;115(5):e7-14. doi: 0.1016/j.ophtha.2008.01.010. Epub 2008 Mar 5..

  35. Lam HS, Ng PC. Biochemical markers of neonatal sepsis. Pathology. 2008 Feb;40(2):141-8. doi: 10.1080/00313020701813735.

  36. Ng PC, Tam BS, Lee CH, Wong SP, Lam HS, Kwok AK, Fok TF. A longitudinal study to establish the normative value and to evaluate perinatal factors affecting intraocular pressure in preterm infants. Invest Ophthalmol Vis Sci. 2008 Jan;49(1):87-92. doi: 10.1167/iovs.07-0954.

  37. Leung AW, Lam HS, Chu WC, Lee KH, Tam YH, Ng PC. Congenital intrathoracic stomach: short esophagus or hiatal hernia? Neonatology. 2008;93(3):178-81. Epub 2007 Sep 24.

  38. Lam HS, Ng PC. Biomarkers in neonatal infection. Biomark Med. 2007 Jun;1(1):133-43. doi: 10.2217/17520363.1.1.133.

  39. Ng PC, Lee CH, Wong SP, Lam HS, Liu FY, So KW, Lee CY, Fok TF. High-dose oral erythromycin decreased the incidence of parenteral nutrition-associated cholestasis in preterm infants. Gastroenterology. 2007 May;132(5):1726-39. Epub 2007 Mar 24.

  40. Li AM, Chan MH, Chan DF, Lam HS, Wong EM, So HK, Chan IH, Lam CW, Nelson EA. Insulin and obstructive sleep apnea in obese Chinese children. Pediatr Pulmonol. 2006 Dec;41(12):1175-81.

  41. Fok TF, Lam HS, Ng PC, Yip AS, Sin NC, Chan IH, Gu GJ, So HK, Wong EM, Lam CW. Fetal methylmercury exposure as measured by cord blood mercury concentrations in a mother-infant cohort in Hong Kong. Environ Int. 2007 Jan;33(1):84-92. Epub 2006 Sep 8.

  42. Lam HS, Chow CM, Poon WT, Lai CK, Chan KC, Yeung WL, Hui J, Chan AY, Ng PC. Risk of vitamin A toxicity from candy-like chewable vitamin supplements for children. Pediatrics. 2006 Aug;118(2):820-4.

  43. Li AM, Tsang TW, Chan DF, Lam HS, So HK, Sung RY, Fok TF. Sputum induction in children with asthma: a tertiary-center experience. Pediatr Pulmonol. 2006 Aug;41(8):720-5.

  44. Ng PC, Lam HS. Diagnostic markers for neonatal sepsis. Curr Opin Pediatr. 2006 Apr;18(2):125-31.

  45. Lee CH, Lau TK, To KF, Lam HS, Chan AW, Ng PC. Congenital systemic Langerhans cell histiocytosis presenting as hydrops fetalis. Acta Paediatr. 2005 Dec;94(12):1843-7.

  46. Lam HS, Chan MH, Ng PC, Wong W, Cheung RC, So AK, Fok TF, Lam CW. Are your hands clean enough for point-of-care electrolyte analysis? Pathology. 2005 Aug;37(4):299-304.


Faculty of Medicine

The Chinese University of Hong Kong

6/F Lui Che Woo Clinical Sciences Building

Prince of Wales Hospital



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The Chinese University of Hong Kong.

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